Publications of C-T Chang

Chen, T.-W.; Liao, H.-W.; Noble, M.; Siao, J.-Y.; Chang, C.-T.: Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions. eLife 13, RP94811 (2024)

Weber, R.; Chang, C.-T.: Human DDX6 regulates translation and decay of inefficiently translated mRNAs. eLife 13, RP92426 (2024)

Enwerem, I.; Elrod, N.; Chang, C.-T.; Lin, A.; Ji, P.; Bohn, J.; Levdansky, Y.; Wagner, E.; Valkov, E.; Goldstrohm, A.: Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome. RNA 27 (4), pp. 44 - 464 (2021)

Arvola, R.; Chang, C.-T.; Buytendorp, J.; Levdansky, Y.; Valkov, E.; Freddolino, P.; Goldstrohm, A.: Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs. Nucleic Acids Research (London) 48 (4), pp. 1843 - 1871 (2020)

Chang, C.-T.; Muthukumar, S.; Weber, R.; Levdansky, Y.; Chen, Y.; Bhandari, D.; Igreja, C.; Wohlbold, L.; Valkov, E.; Izaurralde, E.: A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay. Nucleic Acids Research (London) 47 (17), pp. 9282 - 9295 (2019)

Hanet, A.; Räsch, F.; Weber, R.; Ruscica, V.; Fauser, M.; Raisch, T.; Kuzuoglu-Öztürk, D.; Chang, C.-T.; Bhandari, D.; Igreja, C. et al.; Wohlbold, L.: HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Life science alliance 2 (5), e201900405 (2019)

Raisch, T.; Chang, C.-T.; Levdansky, Y.; Muthukumar, S.; Raunser, S.; Valkov, E.: Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation. Nature Communications 10, 3173 (2019)

Valkov, E.; Muthukumar, S.; Chang, C.-T.; Jonas, S.; Weichenrieder, O.; Izaurralde, E.: Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation. Nature Structural and Molecular Biology 23 (6), pp. 574 - 579 (2016)

Chen, Y.; Boland, A.; Kuzuoğlu-Öztürk, D.; Bawankar, P.; Loh, B.; Chang, C.-T.; Weichenrieder, O.; Izaurralde, E.: A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing. Molecular Cell 54 (5), pp. 737 - 750 (2014)

Chang, C.-T.; Bercovich, N.; Loh, B.; Jonas, S.; Izaurralde, E.: The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Research (London) 42 (8), pp. 5217 - 5233 (2014)

Braun, J.; Truffault, V.; Boland, A.; Huntzinger, E.; Chang, C.-T.; Haas, G.; Weichenrieder, O.; Coles, M.; Izaurralde, E.: A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nature Structural and Molecular Biology 19 (12), pp. 1324 - 1331 (2012)