Publications of C Heim

Steinebach, C.; Bricelj, A.; Murgai, A.; Sosič, I.; Bischof, L.; Ng, Y.; Heim, C.; Maiwald, S.; Proj, M.; Voget, R. et al.; Feller, F.; Košmrlj, J.; Sapozhnikova, V.; Schmidt, A.; Zuleeg, M.; Lemnitzer, P.; Mertins, P.; Hansen, F.; Gütschow, M.; Krönke, J.; Hartmann, M.: Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. Current Medicinal Chemistry 66 (21), pp. 14513 - 14543 (2023)

Kuchta, R.; Heim, C.; Herrmann, A.; Maiwald, S.; Ng, Y.; Sosič, I.; Keuler, T.; Krönke, J.; Gütschow, M.; Hartmann, M. et al.; Steinebach, C.: Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design. RSC Chemical Biology 4 (3), pp. 229 - 234 (2023)

Heim, C.; Spring, A.-K.; Kirchgäßner, S.; Schwarzer, D.; Hartmann, M.: Cereblon neo-substrate binding mimics the recognition of the cyclic imide degron. Biochemical and Biophysical Research Communications 646, pp. 30 - 35 (2023)

Heim, C.; Spring, A.-K.; Kirchgäßner, S.; Schwarzer, D.; Hartmann, M.: Identification and structural basis of C-terminal cyclic imides as natural degrons for cereblon. Biochemical and Biophysical Research Communications 637, pp. 66 - 72 (2022)

Krasavin, M.; Adamchik, M.; Bubyrev, A.; Heim, C.; Maiwald, S.; Zhukovsky, D.; Zhmurov, P.; Bunev, A.; Hartmann, M.: Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines. European Journal of Medicinal Chemistry 246, 114990 (2022)

Krasavin, M.; Bubyrev, A.; Kazantsev, A.; Heim, C.; Maiwald, S.; Zhukovsky, D.; Dar'in, D.; Hartmann, M.; Brunev, A.: Replacing the phthalimide core in thalidomide with benzotriazole. Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), pp. 527 - 530 (2022)

Barkhatova, D.; Zhukovsky, D.; Heim, C.; Maiwald, S.; Hartmann, M.; Krasavin, M.: Synthesis of novel glutarimide derivatives via the Ugi multicomponent reaction: affinity towards the E3 ubiquitin ligase substrate receptor Cereblon. Mendeleev Communications 32 (6), pp. 747 - 749 (2022)

Iskhakova, Z.; Zhuravleva, D.; Heim, C.; Hartmann, M.; Laykov , A.; Forchhammer, K.; Kayumov, A.: PotN represents a novel energy-state sensing PII subfamily, occurring in firmicutes. The FEBS Journal 289 (17), pp. 5305 - 5321 (2022)

Heim, C.; Hartmann, M.: High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen) 78 (3), pp. 290 - 298 (2022)

Maiwald, S.; Heim, C.; Hernandez Alvarez, B.; Hartmann, M.: Correction to "Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay". ACS Medicinal Chemistry Letters 13 (1), pp. 148 - 149 (2021)

Heim, C.; Maiwald, S.; Steinebach, C.; Collins, M.; Strope, J.; Chau, C.; Figg, W.; Gütschow, M.; Hartmann, M.: On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs. Biochemical and Biophysical Research Communications 534, pp. 67 - 72 (2021)

Maiwald, S.; Heim, C.; Hernandez Alvarez, B.; Hartmann, M.: Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay. ACS Medicinal Chemistry Letters 12 (1), pp. 74 - 81 (2020)

Heim, C.; Pliatsika, D.; Mousavizadeh, F.; Bär, K.; Hernandez Alvarez, B.; Giannis, A.; Hartmann, M.: De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. Journal of Medicinal Chemistry 62 (14), pp. 6615 - 6629 (2019)

Boichenko, I.; Bär, K.; Deiss, S.; Heim, C.; Albrecht, R.; Lupas, A.; Hernandez Alvarez, B.; Hartmann, M.: Chemical Ligand Space of Cereblon. ACS Omega 3 (9), pp. 11163 - 11171 (2018)

Eipper, S.; Steiner, R.; Lesner, A.; Sienczyk, M.; Palesch, D.; Halatsch, M.-E.; Zaczynska, E.; Heim, C.; Hartmann, M.; Zimecki, M. et al.; Wirtz, C.; Burster, T.: Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G. PLoS One 11 (3), e0151509 (2016)

Wittenburg, S.; Zuleeg, M.; Peter, K.; Lemnitzer, P.; Voget, R.; Bricelj, A.; Gobec, M.; Dierlamm, N.; Braun, M.; Geiger, T. et al.; Heim, C.; Stakemeier, A.; Wagner, K.; Nowak, R.; Hartmann, M.; Sosič, I.; Gütschow, M.; Krönke, J.; Steinebach, C.: Breaking Barriers in PROTAC Design: Improving Solubility of USP7-Targeting Degraders. (submitted)