Publications
_{^{Transmembrane Signal Transduction}}

Klett, T.; Stahlecker, J.; Jaag, S.; Masberg, B.; Knappe, C.; Lämmerhofer, M.; Coles, M.; Stehle, T.; Boeckler, F.: Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution. ACS Pharmacology & Translational Science Epub ahead (2024)

Stahlecker, J.; Klett, T.; Schwer, M.; Jaag, S.; Dammann, M.; Ernst, L.; Braun, M.; Zimmermann, M.; Kramer, M.; Lämmerhofer, M. et al.; Stehle, T.; Coles, M.; Boeckler, F.: Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C. RSC Medicinal Chemistry 13 (12), pp. 1575 - 1586 (2022)

Dammann, M.; Stahlecker, J.; Zimmermann, M.; Klett, T.; Rotzinger, K.; Kramer, M.; Coles, M.; Stehle, T.; Boeckler, F.: Screening of a Halogen-Enriched Fragment Library Leads to Unconventional Binding Modes. Journal of Medicinal Chemistry 65 (21), pp. 14539 - 14552 (2022)

Escobedo, A.; Piccirillo, J.; Aranda, J.; Diercks, T.; Mateos, B.; Garcia-Cabau, C.; Sánchez-Navarro, M.; Topal, B.; Biesaga, M.; Staby, L. et al.; Kragelund, B.; García, J.; Millet, O.; Orozco, M.; Coles, M.; Crehuet, R.; Salvatella, X.: A glutamine-based single α-helix scaffold to target globular proteins. Nature Communications 13 (1), 7073 (2022)

Skokowa, J.; Hernandez Alvarez, B.; Coles, M.; Ritter, M.; Nasri, M.; Haaf, J.; Aghaallaei, N.; Xu, Y.; Mir, P.; Krahl, A.-C. et al.; Rogers, K.; Maksymenko, K.; Bajoghli, B.; Welte, K.; Lupas, A.; Müller, P.; ElGamacy, M.: A topological refactoring design strategy yields highly stable granulopoietic proteins. Nature Communications 13 (1), 2948 (2022)

Lupas, A.; Pereira, J.; Alva, V.; Merino, F.; Coles, M.; Hartmann, M.: The breakthrough in protein structure prediction. Biochemical Journal 478 (10), pp. 1885 - 1890 (2021)

Hernandez Alvarez, B.; Skokowa, J.; Coles, M.; Mir, P.; Nasri, M.; Weidmann, L.; Rogers, K.; Welte, K.; Lupas, A.; Müller, P. et al.; ElGamacy, M.: Design of novel granulopoietic proteins by topological rescaffolding. PLoS Biology 18 (12), e3000919 (2020)

Toledo-Patiño, S.; Chaubey, M.; Coles, M.; Höcker, B.: Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor. Biochemistry 58 (48), pp. 4790 - 4793 (2019)

ElGamacy, M.; Riss, M.; Zhu, H.; Truffault, V.; Coles, M.: Mapping Local Conformational Landscapes of Proteins in Solution. Structure 27 (5), pp. 853 - 865 (2019)

Adlakha, J.; Karamichali, I.; Sangwallek, J.; Deiss, S.; Bär, K.; Coles, M.; Hartmann, M.; Lupas, A.; Hernandez Alvarez, B.: Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles. Structure 27 (3), pp. 464 - 475 (2019)

ElGamacy, M.; Coles, M.; Lupas, A.: Asymmetric protein design from conserved supersecondary structures. Journal of Structural Biology 204 (3), pp. 380 - 387 (2018)

ElGamacy, M.; Coles, M.; Ernst, P.; Zhu, H.; Hartmann, M.; Plückthun, A.; Lupas, A.: An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture. ACS Synthetic Biology 7 (9), pp. 2226 - 2235 (2018)

Zhu, H.; Sepulveda, E.; Hartmann, M.; Kogenaru, M.; Ursinus, A.; Sulz, E.; Albrecht, R.; Coles, M.; Martin, J.; Lupas, A.: Origin of a folded repeat protein from an intrinsically disordered ancestor. eLife 5 (26), e16761 (2016)

Enthart, A.; Klein, C.; Dehner, A.; Coles, M.; Gemmecker, G.; Kessler, H.; Hagn, F.: Solution structure and binding specificity of the p63 DNA binding domain. Scientific Reports 6, 26707 (2016)

Pozzi, R.; Coles, M.; Linke, D.; Kulik, A.; Nega, M.; Wohlleben, W.; Stegmann, E.: Distinct mechanisms contribute to immunity in the lantibiotic NAI-107 producer strain Microbispora ATCC PTA-5024. Environmental Microbiology 18 (1), pp. 118 - 132 (2016)

Korycinski, M.; Albrecht, R.; Ursinus, A.; Hartmann, M.; Coles, M.; Martin, J.; Dunin-Horkawicz, S.; Lupas, A.: STAC: A New Domain Associated with Transmembrane Solute Transport and Two-Component Signal Transduction Systems. Journal of Molecular Biology 427 (20), pp. 3327 - 3339 (2015)

Hartmann, M.; Boichenko, I.; Coles, M.; Lupas, A.; Hernandez Alvarez, B.: Structural dynamics of the cereblon ligand binding domain. PLoS One 10 (5), e0128342 (2015)

Scharfenberg, F.; Serek-Heuberger, J.; Coles, M.; Hartmann, M.; Habeck, M.; Martin, J.; Lupas, A.; Alva, V.: Structure and evolution of N-domains in AAA metalloproteases. Journal of Molecular Biology 427 (4), pp. 910 - 923 (2015)

Leo, J.; Oberhettinger; Chaubey, M.; Schütz, M.; Kühner, D.; Bertsche, U.; Schwarz, H.; Götz, F.; Autenrieth, I.; Coles, M. et al.; Linke, D.: The Intimin periplasmic domain mediates dimerisation and binding to peptidoglycan. Molecular Microbiology 95 (1), pp. 80 - 100 (2015)

Hartmann, M.; Boichenko, I.; Coles, M.; Zanini, F.; Lupas, A.; Hernandez Alvarez, B.: Thalidomide mimics uridine binding to an aromatic cage in cereblon. Journal of Structural Biology 188 (3), pp. 225 - 232 (2014)